Use of T1 relaxation time in rotating frame (T1ρ) and apparent diffusion coefficient to estimate cerebral stroke evolution

作者：Tan, Yuefa; Xu, Jun; Chen, Ruiying; Chen, Bin; Xu, Juan; Ren, Daokun; Chan, Queenie; Mei, Yingjie; Wu, Yuankui; Xu, Yikai^*

来源：Journal of Magnetic Resonance Imaging, 2018, 48(5): 1247-1254.

DOI：10.1002/jmri.25971

• acute stroke
• brain ischemia
• magnetic resonance imaging
• T1
• apparent diffusion coefficient

BackgroundPurpose/HypothesisThe major factor for the appropriate treatment strategies for ischemia patients is its onset timing. @@@ To study to evaluate the diagnostic accuracy of T-1 relaxation time in a rotating frame (T-1) and apparent diffusion coefficient (ADC) from MRI to estimate ischemia stages. @@@ Study TypePopulation/Subjects/Phantom/Specimen/Animal ModelProspective. @@@ In all, 73 patients (49 males, aged 29-78 years and 24 females, aged 22-94 years) with ischemia were prospectively imaged with T-1 and diffusion MRI during the postischemic period. @@@ Field Strength/SequenceAssessment3T/T-1 and diffusion-weighted imaging (DWI). @@@ Ischemic parenchyma included tissue with elevated signal areas on DWI and correlative hypointense areas on ADC maps. @@@ Statistical TestsResultsThe sensitivity of variables to ischemia time was quantified by analyzing the respective correlations of these values with onset time. @@@ T-1 (ipsilateral-contralateral differences in T-1) (R-2=0.956) and T-1ipsi (ipsilateral ischemia T-1 values) (R-2=0.941) were elevated in all ischemic lesions; these values increased linearly as a function of time, unlike ADC (ipsilateral-contralateral differences in ADC) (R-2=-0.410) and ADC(ipsi) (ipsilateral ischemia ADC values) (R-2=0.550). T-1 and T-1ipsi were significantly different between all stages (P<0.01), except the acute and hyperacute stages (P=0.589 for T-1, P=0.290 for T-1ipsi, respectively), but ADC and ADC(ipsi) only between the late subacute and early subacute stages (P<0.01) and the late subacute and chronic stages (P<0.01). @@@ Data ConclusionThese data suggest that T-1 can provide estimates for the ischemic time in patients. T-1 has the potential to outperform diffusion for single-timepoint examination because the T-1 change during strokes is positive and linear. If patients with suspected stroke are scanned by MRI within the appropriate timeframe, T-1 may provide tools for evaluating stroke onset, potentially aiding in treatment strategies. Level of Evidence: 4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1247-1254.

• 出版日期2018-11
• 单位南方医科大学