Noncovalent immobilization of collagen on the surface of silanized hydroxyapatite

作者：Olaru M^*; Simionescu B C; Cotofana C; Patras X

来源：Optoelectronics and Advanced Materials-Rapid Communications, 2008, 2(11): 726-729.

• Collagen
• Hydroxyapatite
• Sol gel
• Method
• Silanized surface

The aim of this study was to synthesize and characterize a hybrid composite based on type I hydrated collagen, hydroxyapatite and a silane precursor (amino-propyltriethoxysilane). Through sol-gel approach of the precursor and noncovalent immobilization of collagen on the surface of hydroxyapatite, a new type of hybrid material was obtained in which microspheres comprising silica and hydroxyapatite particles are dispersed in an oriented fibrous network of collagen fibrils. Moreover, the sol-gel reactions between the above-mentioned components were not accompanied by conformational changes of the adsorbed collagen, thus preserving its secondary structure.

• 出版日期2008-11