The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children

作者：Liu Shu Qing; Tao Xiao Yan; Yu Peng Cheng; Jin Chun Qiu; Yu Hong Jie; Chen Mei Shun^*; Zhu Wu Yang^*

来源：Biomedical and Environmental Sciences, 2017, 30(5): 373-375.

DOI：10.3967/bes2017.048

• 2-1-1 regimen
• Essen regimen
• PEP
• Preschool children

Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children.

• 出版日期2017-5
• 单位中国疾病预防控制中心