A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands

作者:Petersen Trine P; Ritzen Andreas; Ulven Trond*
来源:Organic Letters, 2009, 11(22): 5134-5137.
DOI:10.1021/ol902101c

摘要

A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.

  • 出版日期2009-11-19