A direct method for the synthesis of indolizine derivatives from easily available aromatic ketones, pyridines, and acrylonitrile derivatives

作者：Cai, Qun; Zhu, Yan-Ping; Gao, Yang; Sun, Jing-Jing; Wu, An-Xin^*

来源：Canadian Journal of Chemistry, 2013, 91(6): 414-419.

DOI：10.1139/cjc-2012-0534

• indolizine derivative
• iodination
• pyridinium ylide synthesis
• 1
• 3-dipolar cycloaddition
• tandem synthesis

A concise and efficient strategy has been proposed to synthesize indolizine derivatives from easily available aryl or heteroaryl methyl ketones, pyridines, and acrylonitriles. The mechanistic pathway involved the integration of iodination, pyridinium ylide synthesis, and 1,3- dipolar cycloaddition. The protocols were found to be highly efficient in terms of high yields, operational simplicity, mild reaction conditions, and easy workup. This method has provided an important supplement for the synthesis of indolizine derivatives via a novel tandem synthesis.

• 出版日期2013-6
• 单位华中师范大学