An Efficient Synthesis of Tri- and Tetrasubstituted Imidazoles from Benzils Using Functionalized Chitosan as Biodegradable Solid Acid Catalyst

作者：Khan Kulsum; Siddiqui Zeba N^*

来源：Industrial & Engineering Chemistry Research, 2015, 54(26): 6611-6618.

DOI：10.1021/acs.iecr.5b00511

An environmentally benign, highly efficient one-pot four-component synthesis of highly functionalized imidazole derivatives using different aldehydes, substituted amines, benzil, and ammonium acetate in the presence of biodegradable and highly efficient catalyst chitosan-SO3H were described. Chitosan-SO3H was found to be a heterogeneous acidic catalyst which allowed easy recovery of the catalyst. Use of microwave irradiation along with chitosan-SO3H for the synthesis of imidazole derivatives makes this protocol green. Moreover, excellent yields, shorter reaction time, chromatography-free purification, and elimination of environmentally hazardous solvents are other advantages of this protocol which leads to sustainability.

• 出版日期2015-7-8