4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

作者：Yang Inho; Yoon Jisoo; Kim Dayoung; Hahn Dongyup; Nam Sang Jip^*; Fenical William^*

来源：Tetrahedron Letters, 2017, 58(24): 2322-2324.

DOI：10.1016/j.tetlet.2017.03.088

• Kromycin derivative
• Pikromycin aglycone
• Marine-derived Streptomyces sp.
• 14-Membered macrolide

HPLC-UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.

• 出版日期2017-6-14