科研之友
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摘要
It could be demonstrated that cervical spinal cord stimulation increases cerebral blood flow. The effects of electrical stimulation of the trigeminal ganglion in the acute phase of SAM in pigs were investigated. The experiments were carried out on 11 domestic pigs divided in two groups (group I: SAM [n = 5]; group II: SAM and trigeminal stimulation [n = 6]). In all animals a native SPECT was performed. The Gasserian ganglion was exposed for inserting the stimulation electrode. SAH was induced by injecting 10 mi autologous blood through a catheter placed in the suprasellar cistern. 30 minutes after SAM-induction electrical stimulation was started for two hours in group 11 (2.8-4.5 V, 50Hz, 300 mus). Tc-99m-HMPAO (400-540 MBq) was injected intravenousely 110 minutes later. In group I 99mTc-HMPAO was applied after the same time interval. 80 minutes later SPECT was performed. Data were processed to calculate the uptake of radioactivity (%/kg tissue weight). The mean values were calculated for the different groups: native animal examination (%/kg tissue weight): 0.6343; group I: 0.468; group II: 0.6533. Comparing the mean values a highly significant difference between group I and group II (p <0.01) and between native examination and group I (p<0.01) could be found. No statistical significance could be detected on comparing the left/right-ratio in any ROI. The electrical stimulation of the Gasserian ganglion leads to a significantly increased uptake of Tc-99m-HMPAO after induced SAM. Maybe the stimulation of the Gasserian ganglion constitutes a new therapeutic modality treating disturbed rCBF after SAH.
- 出版日期2001-3
