Adaptation of Mammalian Auditory Hair Cell Mechanotransduction Is Independent of Calcium Entry

作者：Peng Anthony W; Effertz Thomas; Ricci Anthony J^*

来源：Neuron, 2013, 80(4): 960-972.

DOI：10.1016/j.neuron.2013.08.025

Adaptation is a hallmark of hair cell mechanotransduction, extending the sensory hair bundle dynamic range while providing mechanical filtering of incoming sound. In hair cells responsive to low frequencies, two distinct adaptation mechanisms exist, a fast component of debatable origin and a slow myosin-based component. It is generally believed that Ca2+ entry through mechano-electric transducer channels is required for both forms of adaptation. This study investigates the calcium dependence of adaptation in the mammalian auditory system. Recordings from rat cochlear hair cells demonstrate that altering Ca2+ entry or internal Ca2+ buffering has little effect on either adaptation kinetics or steady-state adaptation responses. Two additional findings include a voltage-dependent process and an extracellular Ca2+ binding site, both modulating the resting open probability independent of adaptation. These data suggest that slow motor adaptation is negligible in mammalian auditory cells and that the remaining adaptation process is independent of calcium entry.

• 出版日期2013-11-20