BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs

作者：Simao, Felipe A.; Waterhouse, Robert M.; Ioannidis, Panagiotis; Kriventseva, Evgenia V.; Zdobnov, Evgeny M.^*

来源：Bioinformatics, 2015, 31(19): 3210-3212.

DOI：10.1093/bioinformatics/btv351

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• TOOL

Motivation: Genomics has revolutionized biological research, but quality assessment of the resulting assembled sequences is complicated and remains mostly limited to technical measures like N50. @@@ Results: We propose a measure for quantitative assessment of genome assembly and annotation completeness based on evolutionarily informed expectations of gene content. We implemented the assessment procedure in open-source software, with sets of Benchmarking Universal Single-Copy Orthologs, named BUSCO.

• 出版日期2015-10-1