Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia

作者：Xu, Yang; Xie, Lianghua; Xie, Jiahong; Liu, Yu; Chen, Wei^*

来源：Chemical communications, 2019, 55(1): 39-42.

DOI：10.1039/c8cc07985d

• IN-VITRO
• COMPLICATIONS
• MULBERRY
• EXTRACT
• DESIGN

A novel strategy for the isolation of anthocyanins was developed by a combination of high-speed countercurrent chromatography (HSCCC) and HPLC techniques. Using this strategy, a novel alpha-glucosidase inhibitor (pelargonidin-3-O-rutinoside, a natural anthocyanin) was isolated from strawberries. Structural determinants for inhibition of alpha-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.

• 出版日期2019-1-4
• 单位浙江大学