Maf1, A New PTEN Target Linking RNA and Lipid Metabolism

作者：Johnson Deborah L^*; Stiles Bangyan L

来源：Trends in Endocrinology and Metabolism, 2016, 27(10): 742-750.

DOI：10.1016/j.tem.2016.04.016

PTEN is a critical tumor suppressor whose dysregulation leads to metabolic disease and cancer. How these diseases are linked at a molecular level is poorly understood. Mafi is a novel PTEN target that connects PTEN's ability to repress intracellular lipid accumulation with its tumor suppressor function. Mafi represses the expression of rRNAs and tRNAs to restrain biosynthetic capacity and oncogenic transformation. Recent studies demonstrate that Mafi also controls intracellular lipid accumulation. In animal models, dysregulation of RNA polymerase I- and III-dependent transcription, and subsequent upregulation of rRNAs and tRNAs, leads to altered lipid metabolism and storage. Together these results identify unexpected connections between RNA and lipid metabolism that may help explain the strong epidemiological association between obesity and cancer.

• 出版日期2016-10