A polysaccharide from Sargassum fusiforme protects against immunosuppression in cyclophosphamide-treated mice

作者：Chen Xiaoming^*; Nie Wenjian; Fan Sairong; Zhang Junfeng; Wang Yanxing; Lu Jianxin; Jin Liqin

来源：Carbohydrate Polymers, 2012, 90(2): 1114-1119.

DOI：10.1016/j.carbpol.2012.06.052

• Sargassum fusiforme
• Polysaccharide
• Immunomodulatory
• Immunosuppession

A water-soluble polysaccharide (SFPS) isolated from Sargassum fusiforme was purified by DEAE-52 cellulose anion-exchange and Sephadex G-200 gel filtration chromatography. The high performance gel permeation chromatography (HPGPC) analysis showed that the average molecular weight (Mw) of SFPS was 299 kDa. The SFPS was composed of D-fucose, L-xylose, D-mannose and D-galactose in a molar ratio of 5.9:1.0:2.3:2.2. The results showed that SFPS stimulated proliferation and the cytokines (IL-2, IL-6 and IFN-gamma) secretion of splenic lymphocytes in cyclophosphamide-induced immunosuppressed mice. SFPS markedly increased the phagocytic rates and cytokines (IL-2. IL-6 and TNF-alpha) secretion of peritoneal macrophages. Administration of SFPS significantly raised spleen index. It could act as an efficacious adjacent immunopotentiating therapy or an alternative means in lessening chemotherapy-induced immunosuppression, and also can be utilized as immunostimulants for food and pharmaceutical industries.

• 出版日期2012-10-1
• 单位温州医科大学