Development and applications of a microfluidic reactor with multiple analytical probes

作者:Greener Jesse*; Tumarkin Ethan; Debono Michael; Kwan Chi Hang; Abolhasani Milad; Guenther Axel; Kumacheva Eugenia
来源:Analyst, 2012, 137(2): 444-450.
DOI:10.1039/c1an15940b

摘要

We report the development of a versatile microfluidic (MF) reactor with multiple analytical probes, which can be used for (i) quantitative characterisation of molecular vibrational signatures of reactants or products, (ii) the localised real-time monitoring of temperature and (iii) site-specific measurements of pH of the reaction system. The analytical probes utilised for in situ reaction analysis include an ATR-FTIR probe, a temperature probe, and a pH probe. We demonstrate the applications of the MF reactor with integrated probes for the parallel monitoring of multiple variables in acid/base neutralisation reaction, of changes in buffer pH, temperature, and vibrational absorption bands, and for monitoring the kinetics of the reaction between CO(2) and a buffer system with therapeutic applications.

  • 出版日期2012