MECHANICAL STIMULATION IMPROVES SURVIVAL IN RANDOM-PATTERN SKIN FLAPS IN RATS

作者：Tacani Pascale Mutti^*; Liebano Richard Eloin; Pinfildi Carlos Eduardo; Gomes Heitor Carvalho; Arias Victor Eduardo; Ferreira Lydia Masako

来源：Ultrasound in Medicine and Biology, 2010, 36(12): 2048-2056.

DOI：10.1016/j.ultrasmedbio.2010.07.020

• Microcirculation
• Necrosis
• Physiologic neovascularization
• Rats
• Surgical flaps
• Ultrasonic therapy
• Ischemia
• Skin
• Plastic surgery
• Physical therapy modalities

This was a study on the effects of 3-MHz ultrasound at 16- and 100-Hz pulse repetition frequencies on angiogenesis and viability of random-pattern skin flaps in rats. A cranially-based dorsal skin flap was raised in 60 EPM-Wistar rats, which were randomly divided into four groups: control, sham, 16-Hz and 100-Hz groups. The mean percentage of necrosis was as follows: control, 42% +/- 13%; sham, 18% +/- 13%; 16-Hz group, 13% +/- 10%; and 100-Hz group, 15% +/- 7%, with significant differences between the control and the other groups (p < 0.001). The mean vascular density was as follows: control, 5% +/- 2%; sham, 7% +/- 2%; 16-Hz group, 21% +/- 4%; and 100-Hz group, 24% +/- 10%, with significant differences between control and ultrasound groups, and between the sham and ultrasound groups (p < 0.001). Both ultrasound treatments (16- and 100-Hz PRFs) induced angiogenesis, and sham and ultrasound treatments improved viability of random-pattern skin flaps in rats. (E-mails: [e-mail]; sandra.dcir@epm.

• 出版日期2010-12