Analysis of Clinical, Histopathological and Follow-Up Data on Transurethral Resections of the Bladder Performed during One Year at a University Centre

作者：Otto W^*; Fritsche H M; Dirmeyer M; Burger M; Straub M; Roessler W; Wieland W F; Denzinger S

来源：Aktuelle Urologie, 2010, 41(5): 316-319.

DOI：10.1055/s-0030-1247481

• transurethral resection of the bladder
• urothelial carcinoma of the bladder
• urocystitis
• residual tumour rate
• recurrence
• instillation therapy
• cystectomy

Introduction: Transurethral resection of the bladder (TURB) is one of the most common surgical treatments in urology. We examined the TURBs that had been carried out during one year for suspected bladder cancer (first findings and recurrence) and then analysed the further clinical courses of these patients within the first twelve months after TURB.
Materials and Methods: We recorded retrospectively the course of 160 patients in whom altogether 210 elective TURBs had been performed in our clinic between April 2007 and March 2008 (observation period). In addition, the patients' further clinical course within the first twelve months after TURB was recorded (follow-up period). All initial and recurrence TURB were carried out with photodynamic diagnosis; the histological evaluation was performed at a university centre.
Results: 71% of the 118 initial resections performed during the observation period showed urothelial cell carcinoma of the bladder - pTa (61%), pT1 (20%), pT2-4 (17%), Cis (2%) while 60 re-TURBs in the whole period detected 17% residual tumours. According to the guidelines, 18 patients (14%) received instillation therapy with mitomycin C, 32 patients (25%) with Bacillus Calmette-Guerin (BCG). Cystectomies were performed on 23 patients (18%). 18TURBs after suspected recurrence in the follow-up period confirmed recurrence in 28%, which represents a recurrence rate of 4%. In the same period 5 patients (4%) developed distant metastases, two patients (2%) died. Two patients (7%) with initially benign findings developed bladder cancer in the follow-up period.
Conclusion: We present an analysis of TURBs performed at a university centre. When bladder cancer is diagnosed in 7% within one year after urocystitis has been detected in the initial TURB findings, regular follow-up examination of these patients, especially with certain risk profiles, has to be discussed.

• 出版日期2010-9