A measurement system analysis with design of experiments: Investigation of the adhesion performance of a pressure sensitive adhesive with the probe tack test

作者：Michaelis Marc; Leopold Claudia S^*

来源：International Journal of Pharmaceutics, 2015, 496(2): 448-456.

DOI：10.1016/j.ijpharm.2015.09.061

• Pressure sensitive adhesive
• Probe tack test
• Rheology
• Measurement system analysis
• Design of experiments
• Transdermal patch

The tack of a pressure sensitive adhesive (PSA) is not an inherent material property and strongly depends on the measurement conditions. Following the concept of a measurement system analysis (MSA), influencing factors of the probe tack test were investigated by a design of experiments (DoE) approach. A response surface design with 38 runs was built to evaluate the influence of detachment speed, dwell time, contact force, adhesive film thickness and API content on tack, determined as the maximum of the stress strain curve (sigma(max)). It could be shown that all investigated factors have a significant effect on the response and that the DoE approach allowed to detect two-factorial interactions between the dwell time, the contact force, the adhesive film thickness and the API content. Surprisingly, it was found that tack increases with decreasing and not with increasing adhesive film thickness.

• 出版日期2015-12-30