A pre-structured helix in the intrinsically disordered 4EBP1

作者：Kim Do Hyoung; Lee Chewook; Cho Ye Jin; Lee Si Hyung; Cha Eun Ji; Lim Ji Eun; Sabo T Michael; Griesinger Christian; Lee Donghan; Han Kyou Hoon^*

来源：Molecular Biosystems, 2015, 11(2): 366-369.

DOI：10.1039/c4mb00532e

The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.

• 出版日期2015