Metal-Organic Framework [Cd(LTP)2]n for Improved Enantioseparations on a Chiral Cyclodextrin Stationary Phase in GC

作者：Yang, Jiang-rong; Xie, Sheng-ming; Zhang, Jun-hui; Chen, Ling; Nong, Rui-yu; Yuan, Li-ming^*

来源：Journal of Chromatographic Science, 2016, 54(9): 1467-1474.

DOI：10.1093/chromsci/bmw111

• LIQUID-CHROMATOGRAPHIC SEPARATION
• TUBULAR CAPILLARY ELECTROCHROMATOGRAPHY
• HIGH-PERFORMANCE SEPARATION
• GAS-CHROMATOGRAPHY
• BETA-CYCLODEXTRIN
• ENANTIOSELECTIVE RECOGNITION
• IMIDAZOLATE FRAMEWORK-90
• BACILLUS-CIRCULANS
• COATED CAPILLARY
• FABRICATION

Metal-organic frameworks (MOFs) are a class of novel porous materials consisting of clusters or chains of metal ions and organic linkers. The chiral MOF [Cd(LTP)(2)](n) (LTP = L(-)-thiazolidine-4-carboxylic acid) possesses infinite extension three-dimensional supramolecular reticular structure with right-handed helix. In this work, three capillary columns (A, B and C) containing MOF [Cd(LTP)(2)](n), permethylated beta-cyclodextrin (CD) and sodium chloride, and MOF [Cd(LTP)(2)](n) and permethylated beta-CD, respectively, have been prepared and their respective enantioseparation abilities have been investigated. The polarities of all of the MOFs and permethylated beta-CDs are moderate. The numbers of theoretical plates (plate m(-1)) of the three columns have been measured using n-dodecane at 120 degrees C, which followed an increasing order of A (3100) < B (3800) < C (4300). Some racemates were separated with different resolutions on Columns A, B and C. The results indicated that the incorporated MOF [Cd(LTP)(2)](n) enhanced the separations of racemates on a permethylated beta-CD stationary phase with high column efficiency and good reproducibility in gas chromatography.

• 出版日期2016-10
• 单位云南师范大学; 华东师范大学