Dark field microscopic analysis of discrete Au nanostructures: Understanding the correlation of scattering with stoichiometry

作者：Wang Guoqing; Bu Tong; Zako Tamotsu^*; Watanabe Tamaki Ryoko; Tanaka Takuo; Maeda Mizuo^*

来源：Chemical Physics Letters, 2017, 684: 310-315.

DOI：10.1016/j.cplett.2017.07.012

• Gold nanoparticle
• Nanostructure
• Dark field microscopy
• Sensitive detection
• Scattering intensity
• Single cluster analysis

Due to the potential of gold nanoparticle (AuNP)-based trace analysis, the discrimination of small AuNP clusters with different assembling stoichiometry is a subject of fundamental and technological importance. Here we prepare oligomerized AuNPs with controlled stoichiometry through DNA-directed assembly, and demonstrate that AuNP monomers, dimers and trimers can be clearly distinguished using dark field microscopy (DFM). The scattering intensity for of AuNP structures with stoichiometry ranging from 1 to 3 agrees well with our theoretical calculations. This study demonstrates the potential of utilizing the DFM approach in ultra-sensitive detection as well as the use of DNA-directed assembly for plasmonic nano-architectures.

• 出版日期2017-9-16
• 单位RIKEN