Long-term Follow-up of Borderline Ovarian Tumors Clinical Outcome and Prognostic Factors

作者：Lazarou Anastasia; Fotopoulou Christina; Coumbos Alexandra; Sehouli Jalid^*; Vasiljeva Jekaterina; Braicu Ioana; Burger Heinz; Kuehn Wolfgang

来源：Anticancer Research, 2014, 34(11): 6725-6730.

• Borderline ovarian tumor
• implants
• relapse
• surgery
• prognosis

Aim: The aim of the present study was to evaluate the characteristics of borderline ovarian tumors (BOTs). Patients and Methods: Data of 151 patients with BOTs were retrospectively evaluated. Results: A total of 151 cases with BOTs were diagnosed. Histopathological evaluation identified 82.8% with serous, 10.6% with mucinous and 5.3% with mixed histology. Overall, 67.5% had International Federation of Gynecology and Obstetrics (FIGO) stage I, 10.6% FIGO stage II, 14.6% FIGO stage III and 4% FIGO stage IV. A total of 21.9% hurl peritoneal implants; of which 2.7% were invasive, 17.2% non-invasive and 2% both invasive and non-invasive. Microinvasion was observed in 5.3% and a micropapillary pattern in 12.6%. A total of 12.6% of patients presented second neoplasms. During a median follow-up period of 86 (range=0.1-432) months, there were relapses in 16.8%, of which 52.6% had invasive implants. Overall, 6.2% died of their disease, 28.5% with invasive implants. The median time-to-progression was 48 (range=8-120) months. Conclusion: Patients with BOTs have an excellent prognosis. Long-term follow-up is recommended, since recurrence occurs.

• 出版日期2014-11