A stimulating way to improve T cell responses to poxvirus-vectored vaccines

作者：Isaacs Stuart N^*

来源：Journal of Clinical Investigation, 2011, 121(1): 19-21.

DOI：10.1172/JCI45726

Vaccines remain one of the most cost-effective public health measures Despite ongoing efforts, protective vaccines against cancer and many infectious diseases, including malaria, tuberculosis, and HIV/AIDS, are still not in hand Most investigators believe that to succeed against these difficult targets, vaccines that generate potent T cell responses are needed In this issue of the Salek-Ardakani et al show how the relative virulence of a virus/vaccine vector affects the memory CD8(+) T cells generated and how the response may be enhanced The work has important implications for the development of future vaccines that aim to trigger CD8(+) T cell responses

• 出版日期2011-1