Four-component, five-centered, one-pot synthesis of 1-(1H-tetrazol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole derivatives

作者：Reddy B V Subba^*; Kota Kavya; Rao B Maheshwar; Sridhar B; Mukkanti K^*

来源：Tetrahedron Letters, 2016, 57(41): 4529-4532.

DOI：10.1016/j.tetlet.2016.08.067

• Multi-component reaction
• Haloamine cyclization
• Ugi-azide coupling
• Tetrahydrocarbolines
• Tetrazoles

An efficient four component, five centered coupling strategy has been developed for the synthesis of a novel series of 1-tetrazolyl-tetrahydro-beta-carboline derivatives in good yields. This method is effective for the synthesis of tetrazolyl tetrahydro-beta-carbolines in a one-pot operation. This method is operationally simple and works under mild conditions with diverse substrates.

• 出版日期2016-10-12