Naturally bioactive compounds from Hemimycale aff arabica: antimicrobial, antiglycation, cytotoxicity, and molecular docking studies

作者：Shaaban Mohamed^*; Hassan Amal Zaki; Soltan Maha M^*; Abdelwahab Ahmed B

来源：Medicinal Chemistry Research, 2018, 27(9): 2079-2088.

DOI：10.1007/s00044-018-2217-6

• Cyclic urea derivatives
• Hemimycale aff arabica
• Antimicrobial
• Antiglycation
• Cytotoxicity
• Docking study

Two naturally new cyclic urea and amide derivatives, [1,3]-diazepan-2-one (1) and (S)-1,4-diaza-cyclododecane-2,3-dion (2), were isolated from the organic extract of the sponge Hemimycale aff arabica collected from the Red Sea. This was together with 4-acetamido-2,6-dibromo-4-hydroxy-1,1-dimethoxycyclohexa-2,5-diene (3), 2,4-bis(1-methyl-1-phenylethyl)-phenol (4), beta-sitosterol (5), bis-[2-ethyl]-hexyl-phthylester, triglyceride fatty acid ester, and linoleic acid. The chemical structures of compounds 1 and 2 were determined based on 1D and 2D Nuclear Magnetic Resonance (NMR) and HR-ESIMS. Compounds 1 and 2 revealed high potency as antiglycated agents. The molecular docking study of compounds 1 and 2 using alpha-glucosidase, alpha-amylase, dipeptidyl peptidase-IV, and glycogen synthase kinase was performed to check their efficiency as hypoglycemic agents. Both the sponge extract and compound 1 showed no cytotoxicity vs. the RPE-1 as a model of normal cell line.

• 出版日期2018-9