Androgen regulates apoptosis-related signaling pathway to reverse bone marrow-derived mesenchymal stem cells (BMSCs)-induced SGC-7901 cell death

作者：Zhang, Lin; Zheng, Jiantao^*; Liu, Yijuan; Li, Liangqing

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(12): 16154-16162.

• BMSCs
• androgen
• SGC-7901 cell
• gastric cancer

Androgen and human bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to relate closely with cancer progression. However, there is little literature to report the association between androgen and BMSCs in gastric cancer (GC). In this study we focus on the role of androgen and BMSCs regulation of growth, migration and apoptosis in SGC-7901 cells and underlying molecular mechanisms. The results demonstrated that BMSCs could significantly inhibit SGC-7901 cells growth compared with control group. Androgen significantly reversed BMSCs-induced SGC-7901 cells growth inhibition. Moreover, we observed significant decrease in SGC-7901 cells migration and increase in apoptosis in co-cultured system. Androgen showed an antagonistic effect in BMSCs-induced SGC-7901 cells migration inhibition and apoptosis in co-cultured system. Furthermore, the results of underlying molecular mechanisms indicated that BMSCs induced SGC-7901 cells growth and migration inhibition and apoptosis by enhancing TNF-alpha/JNK activation. However, androgen could inhibit TNF-alpha/JNK signaling cascades in BMSCs and SGC-7901 co-cultured system. In conclusion, BMSCs can promote SGC-7901 cells apoptosis, which may be associated with the activation of TNF-alpha/JNK signaling cascades. Androgen plays an important role in SGC-7901 cells proliferation and may be a novel therapeutic target for GC treatment.

• 出版日期2017
• 单位福建医科大学