NEW WITHANOLIDE, ACYL AND MENTHYL GLUCOSIDES FROM FRUITS OF WITHANIA COAGULANS DUNAL

作者：Ali Abuzer; Jameel Mohd; Ali Mohammed^*

来源：Acta Poloniae Pharmaceutica, 2014, 71(3): 423-430.

• Withania coagulans
• Solanaceae
• fruits
• menthyl tetraglucoside
• withacoagulinyl tetraglucoside
• capryloyl hexaglucoside

The fruits of Withania coagulans Dunal (family: Solanaceae) are sweet, sedative, emetic, alterative and diuretic; used to treat asthma, biliousness, strangury, wounds, dyspepsia, flatulent colic, liver complaints and intestinal infections. Phytochemical investigation of the fruits yielded a withanolide tetraglucosidc identi field as (20S, 22R)-5 alpha, 20 alpha-diacetoxy-6 beta-hydroxy-1-oxowitha-2,24-dienolide-6-beta-D-glucopyranosyl-(6'-> 1")-beta-D-glucopyranosyl-(6"-> 1"')-beta-D-glucopyranosyl-(6a -> 1b)-beta-D-glucopyranosyl-(6b -> 1c)-beta-D-glucopyranosyl-(6c -> 1d)-beta-D-glucopyranosyl-(6d -> 1e)-glucopyranosyl-(6e -> 1f)-glucopyranoside and a menthyl tetraglucoside characterized as menthol-O-alpha-L-glucopyranosyl-(2a -> 1b)-O-alpha-L-glucopyranosyl-(2b -> 1c)-O-alpha-L-glucopyranoside along with three fatty acid esters, n-nonacosanyl linolenate, n-octacosanyl linolenate and n-heptacosanyl linolenate. The structures of the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical means.

• 出版日期2014-6