Postnatal Cytomegalovirus Infection Through Human Milk in Preterm Infants Transmission, Clinical Presentation, and Prevention

作者：Hamprecht Klaus^*; Goelz Rangmar

来源：Clinics in Perinatology, 2017, 44(1): 121-+.

DOI：10.1016/j.clp.2016.11.012

• Cytomegalovirus
• Lactation
• Native breast milk
• Virus reactivation
• Short- and long-term outcome
• Very low birth weight infants (VLBW)
• Virus inactivation
• Ganciclovir

Cytomegalovirus (CMV) is reactivated in the lactating breast in up to 96% of CMV seropositive mothers. There is a relevant entity of postnatally acquired symptomatic CMV infection and disease of preterm infants through raw breast milk (BM). Actual data support negative influence on long-term cognitive development. Concerning prevention, only heat inactivation eliminates virus infectivity, and short-term heat inactivation is most preservative; this can be applied effectively under routine conditions. Short-term heat inactivation for 5 minutes at 62 degrees C maintains the benefits of feeding BM without the disadvantages of CMV transmission.

• 出版日期2017-3
• 单位河北医科大学