Amination of Allylic Alcohols in Water at Room Temperature

作者:Nishikata Takashi; Lipshutz Bruce H*
来源:Organic Letters, 2009, 11(11): 2377-2379.
DOI:10.1021/ol900235s

摘要

The "trick" to carrying out regiocontrolled aminations of allylic alcohols in water as the only medium is use of a nanomicelle's interior as the organic reaction solvent. When HCO(2)Me is present, along with the proper base and source of catalytic Pd, allylic amines are cleanly formed at room temperature.

  • 出版日期2009-6-4