Association of Preference-Based Health-Related Quality of Life with Weight Loss in Obese Adults

作者：Lester Erica LW; Padwal Raj; Majumdar Sumit R; Ye F; Birch Daniel W; Klarenbach Scott W^*

来源：Value in Health, 2017, 20(4): 694-698.

DOI：10.1016/j.jval.2016.04.016

• body mass index
• obesity
• quality of life

Background: The obesity epidemic is linked to substantial health care resource use, reduction in workforce and home productivity, and poor health-related quality of life (HRQOL). Changes in body mass index (BMI) are associated with improvements in HRQOL; the nature of this relationship, however, has not been reliably described. Objectives: To determine the independent association between changes in BMI and change in utility-based HRQOL. Methods: Data were prospectively collected on 500 severely obese adult patients enrolled in a single center obesity management clinic. Univariable and multivariable linear regressions were performed, adjusting for the effect of the intervention itself, obesity-related comorbidities, BMI at enrollment, age, and sex. Results: A 1-unit reduction in BMI was associated with a 0.0075 (95% confidence interval 0.0041-0.0109) increase in the EuroQol five-dimensional questionnaire score. This relationship was unaltered in various analyses, and is likely applicable to any health-care-induced changes in BMI. Conclusions: The quantification of this association advances the understanding of the clinical benefits of interventions that affect BMI, and can inform more robust cost-utility analyses.

• 出版日期2017-4