Are low-intensity induction strategies better for older patients with acute myeloid leukemia?

作者：Roboz Gail J^*; Wissa Usama; Ritchie Ellen K; Gergis Usama; Mayer Sebastian; Scandura Joseph M; Christos Paul J; Feldman Eric J

来源：Leukemia Research, 2012, 36(4): 407-412.

DOI：10.1016/j.leukres.2011.12.019

• Leukemia
• Acute
• Myeloid
• Drug therapy
• Clinical trials
• Aged
• Remission induction

This study compares outcomes of low-intensity versus standard-intensity induction strategies for older patients with acute myeloid leukemia at the Weill Cornell Leukemia Program. From 1999 to 2009, 298 adults >= 60 years with AML underwent induction chemotherapy with low-intensity and standard-intensity regimens, based on physician and patient preferences and investigational protocol availability. Overall, 33% of the cohort achieved complete remission with initial treatment, 23% with low-intensity induction and 53% with standard-intensity induction (P < 0.0001). The median overall survival was 6.5 months and there was no significant difference in overall survival between patients initially treated with a low-intensity regimen compared to those receiving standard-intensity induction. There were no differences in 30- or 60-day mortality between the two groups.

• 出版日期2012-4