A Positive Correlation between Hydrogen Peroxide and Soluble TNF-Alpha Receptor 2 Early in Maternal Blood and At Term in Placenta of Pregnant Women with Preeclampsia

作者：Leblanc Samuel; Ouellet Annie; Giguere Yves; Forest Jean Claude; Moutquin Jean Marie; Aris Aziz^*

来源：Hypertension in Pregnancy, 2012, 31(3): 357-366.

DOI：10.3109/10641955.2010.525281

• Hydrogen peroxide
• Maternal blood
• Placenta
• Preeclampsia
• Soluble TNF-R2

Objectives. We hypothesized that hydrogen peroxide (H2O2) and soluble TNF-alpha receptor 2 (sTNF-R2) co-play a role in the pathogenesis of preeclampsia. Methods. Correlation of H2O2 and sTNF-R2 was assessed in vivo in maternal blood and placenta, and in vitro in cytotrophoblasts culture. Results. We showed a positive correlation between increased levels of H2O2 and sTNF-R2 early at 10-15 gestational weeks and at term in maternal serum, and in placenta of women with preeclampsia. Our in vitro experiments showed that H2O2 induced the placental synthesis of sTNF-R2. Conclusion. We propose to consider H2O2 and sTNF-R2 as potential biomarkers in predicting preeclampsia.

• 出版日期2012