LOX-1 expression and oxidized LDL uptake and toxicity in the HN33 neuronal cell line

作者：Mao Xiaoou; Xie Lin; Greenberg David A^*

来源：Neuroscience Letters, 2014, 580: 182-185.

DOI：10.1016/j.neulet.2014.03.061

• Neurodegeneration
• LOX-1
• Ox-LDL
• HN33 cells
• Hypoxia

Cardiovascular risk factors appear to influence the risk and progression of neurodegenerative disease, but the mechanisms involved are poorly understood. We investigated the possible involvement of oxidized low-density lipoprotein receptor (LOX-1) and oxidized low-density lipoprotein (Ox-LDL) in neurodegeneration by studying the expression of LOX-1 and the effects of Ox-LDL in HN33 cells, a neuronal cell line of central nervous system origin. HN33 cells showed LOX-1 protein expression, hypoxic induction of LOX-1, Ox-LDL uptake and Ox-LDL toxicity. LOX-1/Ox-LDL signaling may contribute to the association between cardiovascular risk factors and neurodegenerative disease.

• 出版日期2014-9-19