A New Xanthene from Desmostachya bipinnata (L.) Stapf Inhibits Signal Transducer and Activator of Transcription 3 (STAT3) and Low-density Lipoprotein-Oxidation

作者：Shrestha Sabina; Park Ji Hae; Lee Dae Young; Cho Jin Gyeong; Cui En ji; Chung In Sik; Kwon Byoung Mog; Cho Moon Hee; Jeong Tae Sook; Baek Nam In^*

来源：Journal of the Korean Society for Applied Biological Chemistry, 2011, 54(2): 308-311.

DOI：10.3839/jksabc.2011.049

• Desmostatchya bipinnata
• 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one
• low-density lipoprotein-oxidation
• signal transducer and activator of transcription

A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC(50) value of 5 mu M and low-density lipoprotein-oxidation with IC(50) value of 27.2 mu M.

• 出版日期2011-4