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摘要
This paper describes the synthesis and characterization of a series of poly(2-hydroxyethyl methacrylate) (pHEMA)-based hydrogel lenses coated with poly(ethylene glycol) (PEG) chains. A novel tri-branched PEG-substituted hydrazide is synthesized, which imparts densely packed, covalently bound PEG layers on hydrogels, to determine whether branching provides improved coverage of the lens surface, thereby reducing protein adsorption. Surface modification of hydrogels with PEG was performed via amide-coupling reactions between PEG-substituted hydrazide and the pHEMA matrix. Protein adsorption, water content, optical transparency, and surface properties of the hydrogels were investigated. The hydrogels exhibited transmittance of >90% and improved surface hydrophilicity. Notably, the amount of lysozyme adsorbed on tri-branched PEG-coated hydrogels decreased significantly compared to the amount adsorbed onto the surface of control and linear PEG-coated hydrogels. These results provide insight into the mechanism by which PEGs reduce lysozyme adsorption and suggest that PEG coating may offer an intriguing potential for ophthalmic biomaterials as well as protein-resistant devices.
- 出版日期2015-11
