A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe

作者:Albertoni Barbara; Hannam Jeffrey S; Ackermann Damian; Schmitz Anton; Famulok Michael*
来源:Chemical Communications, 2012, 48(9): 1272-1274.
DOI:10.1039/c2cc16477a

摘要

The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples.

  • 出版日期2012