科研之友
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摘要
Cupric chloride showed efficient catalytic activity for the cross coupling reaction of arylboronic acids and (hydroxyimino)ethylcoumarins at room temperature in the presence of NEt3 as base. A simple and convenient protocol for the synthesis of O-aryloxime ethers having the highly base sensitive coumarin nucleus is reported. O-Aryloxime ethers are important as they provide access to scaffolds for the generation of various biologically active compounds. They are potential precursors to benzofurans and benzisoxazoles.
- 出版日期2012-1
