Nationwide Surveillance Study of Vancomycin-Intermediate Staphylococcus aureus Strains in Korean Hospitals from 2001 to 2006

作者：Chung Gyungtae; Cha Jeongok; Han Sunyoung; Jang Heesun; Lee Kyeongmin; Yoo Jaeil; Yoo Jeongsik; Kim Hongbin; Eun Soohoon; Kim Bongsu; Park Ok; Lee Yeong Seon^*

来源：Journal of Microbiology and Biotechnology, 2010, 20(3): 637-642.

DOI：10.4014/jmb.0906.06018

• Staphylococcus aureus
• surveillance
• vancomycin-intermediate

We investigated the prevalence and the molecular characteristics of vancomycin-intermediate Staphylococcus aureus (VISA) among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical samples at tertiary or general hospitals participating in a nationwide surveillance program for VISA and vancomycin-resistant Staphylococcus aureus (VRSA) in Korea during an 8-week period in each year from 2001 to 2006. Of 41,639 MRSAs isolated, 37,856 were screened and 169 grew on brain heart infusion agar supplemented with 4 mu g/ml vancomycin. A vancomycin MIC of 4 mu g/ml was confirmed for 33 VISA isolates of the 169 isolates. Eighteen of the 33 isolates were classified as hetero-VISA (hVISA) by the population analysis profile (PAP) method. All VISA isolates were susceptible to linezolid, tigecycline, and quinupristin dalfopristin. Most VISA isolates (MIC 4 mu g/ml) showed a PFGE C pattern with sec, seg, and sei enterotoxin genes, including ST5-SCCmec type II, or a PFGE A pattern with sea, including ST239-SCCmec type III.

• 出版日期2010-3