Association of X-box binding protein 1 (XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episode

作者：Grunebaum Michael F^*; Galfalvy Hanga C; Huang Yung Yu; Cooper Thomas B; Burke Ainsley K; Agnello Melissa; Oquendo Maria A; Mann J John

来源：International Journal of Neuropsychopharmacology, 2009, 12(2): 281-283.

DOI：10.1017/S1461145708009863

• Cortisol
• endoplasmic reticulum stress
• genetics
• major depressive disorder
• unfolded protein response

Brain diseases including Alzheimer's and Parkinson's involve the cellular 'unfolded protein' (UPR) stress response. Psychiatric illnesses such as depressive disorders are thought to involve brain stress-response pathways. The XBP1 gene encodes a key transcription factor in the UPR stress response and therefore could be involved in the pathophysiology of depressive disorders. A functional polymorphism (-116C -> G) in the XBP1 promoter was linked in some studies to bipolar disorder. Among 132 adults (mean age 39 yr) who presented with a major depressive episode, this polymorphism was found to be associated with a worse course during 1-yr prospective follow-up. In a subgroup (n=22), the polymorphism was associated with higher plasma levels of the stress hormone cortisol. The results suggest that hypothalamic-pituitary-adrenocortical and cellular stress pathways involving the XBP1 gene may be involved in the pathophysiology of major depressive disorder. These relationships merit further study.

• 出版日期2009-3