Architecture of the human mTORC2 core complex

作者：Stuttfeld Edward; Aylett Christopher H S; Imseng Stefan; Boehringer Daniel; Scaiola Alain; Sauer Evelyn; Hall Michael N^*; Maier Timm^*; Ban Nenad^*

来源：eLife, 2018, 7: e33101.

DOI：10.7554/elife.33101

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.

• 出版日期2018-2-9