科研之友
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摘要
Background UbcH10 is an important regulator for the mitotic spindle assembly checkpoint pathway that regulates cell-cycle progression. Overexpression of UbcH10 significantly correlated with advanced tumor grade and high cell proliferation. Methods The expression of UbcH10 and Ki-67 in meningioma tissues were evaluated immunohistochemically in 47 patients with meningiomas. The correlation of UbcH10 immunoreactivity with clinicopathological features and the prognostic value of UbcH10 in patients were also analyzed. Results Immunohistochemistry showed an increase in UbcH10 labeling index in atypical and anaplastic meningiomas versus classical meningiomas (10.53 +/- 5.79% vs. 4.23 +/- 2.85%, P?<?0.001). There was a positive correlation between UbcH10 and Ki-67 immunoreactivity (Spearman r= 0.77, P<?0.001). Clinicopathological evaluation suggested that UbcH10 expression was associated with tumor grade and recurrence (P?<?0.05). KaplanMeier survival analysis and Cox multivariate analysis revealed a significant correlation between high levels of UbcH10 immunoreactivity and high rates of tumor recurrence. Conclusion We conclude that UbcH10 may play important roles in the development of meningioma, high UbcH10 labeling index indicates higher grade of meningioma, and UbcH10 may be a useful molecular marker for predicting the prognosis of meningioma. J. Surg. Oncol. 2012; 106:327-331.
- 出版日期2012-9
- 单位天津市中医药研究院附属医院; 中国人民解放军第二军医大学
