Attenuation Correction Synthesis for Hybrid PET-MR Scanners: Application to Brain Studies

作者：Burgos Ninon^*; Cardoso M Jorge; Thielemans Kris; Modat Marc; Pedemonte Stefano; Dickson John; Barnes Anna; Ahmed Rebekah; Mahoney Colin J; Schott Jonathan M; Duncan John S; Atkinson David; Arridge Simon R; Hutton Brian F; Ourselin Sebastien

来源：IEEE Transactions on Medical Imaging, 2014, 33(12): 2332-2341.

DOI：10.1109/TMI.2014.2340135

• Attenuation correction
• image synthesis
• positron emission tomography/magnetic resonance (PET/MR)

Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient%26apos;s morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.

• 出版日期2014-12