A one-pot synthesis of a branched tertiary phosphine oxide from red phosphorus and 1-(tert-butyl)-4-vinylbenzene in KOH-DMSO: an unusually facile addition of P-centered nucleophiles to a weakly electrophilic double bond

作者：Trofimov Boris A; Malysheva Svetlana F; Gusarova Nina K; Kuimov Vladimir A; Belogorlova Nataliya A; Sukhov Boris G^*

来源：Tetrahedron Letters, 2008, 49(21): 3480-3483.

DOI：10.1016/j.tetlet.2008.03.097

• red phosphorus
• styrene
• 1-(tert-butyl)-4-vinylbenzene
• superbases
• nucleophilic addition
• tris[4-(tert-butyl)phenethyl]phosphine oxide
• microwave activation

Red phosphorus reacts with 1-(tert-butyl)-4-vinyl benzene in a superbase media (KOH-DMSO, 90-100 degrees C, 3 h) to give tris[4-(tert-butyl)phenethyl]phosphine oxide in 77% yield. Microwave activation of the reaction affords the phosphine oxide in 82% yield in 6 min.

• 出版日期2008-5-19