Aberrantly regulated proteins in frontotemporal dementia

作者：Schweitzer Kelly^*; Decker Emily; Zhu Liping; Miller Richard E; Mirra Suzanne S; Spina Salvatore; Ghetti Bernardino; Wang Mu; Murrell Jill

来源：Biochemical and Biophysical Research Communications, 2006, 348(2): 465-472.

DOI：10.1016/j.bbrc.2006.07.113

• frontotemporal dementia and parkinsonism linked to chromosome 17
• matrix-assisted laser desorption/ionization time-of-flight
• oxidative stress
• two-dimensional electrophoresis
• ubiquitin C-terminal hydrolyase L1
• UCHL1

Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

• 出版日期2006-9-22