Double blind clinical trial in a series of 115 patients with seborrheic dermatitis: prevention of relapses using a topical modulator of Toll Like Receptor 2

作者：Ionescu M A^*; Baroni A; Brambilla L; Cannavo S P; Cristaudo A; Vedove C Dalle; Frasca M; Girolomoni G; Gnecchi L; Peris K; Trifiro C; Matta A M; Robert G

来源：Giornale Italiano di Dermatologia e Venereologia, 2011, 146(3): 185-189.

• Recurrence, prevention and control
• Dermatitis, seborrheic
• Toll-like receptors

Aim. Seborrheic dermatitis is a chronic inflammatory disease aggravated by Malassezia species. Toll-like receptors (TLR) are part of innate immune system that can be activated by yeasts. Previous studies showed that an association of Ombelliferae extract with a lipid (TLR2-Regul (TM)) decreases the IL-8 expression in human skin in contact with M. furfur. The aim of this study was to assess the activity of a topical formulated with TLR2-Regul (TM) in the prevention of seborrheic dermatitis (SD) relapses.
Methods. Immune-competent SD adult patients were treated for SD (topical imidazoles or steroids). Cleared patients were randomized and received a topical containing TLR2-Regul (TM) (A) or its vehicle (B). Erythema, scales and pruritus were assessed during two months.
Results. The study included 115 patients, mean age 43.4, sex ratio m/f 1.5. At week 4 the relapse rate was 26% (N.=15) in group A and 43% (N.=25) in group B. At W8 the relapse rate was 21% (N.=12) in group A and 40% (N.=23) (P=0.0309).
Conclusion. In this series of 115 adults with seborrheic dermatitis, patients treated with a topical containing TLR-Regul (TM) showed a significantly less relapse rate compared with the excipient group (P<0.05). TLR modulation could represent a new therapeutic approach in the prevention of seborrheic dermatitis relapses.

• 出版日期2011-6