Abnormal Myocardial Energy-Production State in Mitochondrial Cardiomyopathy and Acute Response to L-Arginine Infusion - C-11 Acetate Kinetics Revealed by Positron Emission Tomography

作者：Arakawa Kenichiro; Kudo Takashi; Ikawa Masamichi; Morikawa Norihiro; Kawai Yasuyuki; Sahashi Ko; Lee Jong Dae; Kuriyama Masaru; Miyamori Isamu; Okazawa Hidehiko; Yoneda Makoto^*

来源：Circulation Journal, 2010, 74(12): 2702-2711.

DOI：10.1253/circj.CJ-10-0044

• Acetate positron emission tomography
• Cardiomyopathy
• L-arginine
• MELAS

Background: Cardiomyopathy is a life-threatening condition in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (known as MELAS). However, no effective therapy has been available until now. In the present study cardiac energetics and acute effects of L-arginine (Arg) were evaluated in MELAS patients.
Methods and Results: The 6 patients with MELAS (M-group) and 6 volunteers (C-group) underwent dynamic C-11 acetate positron emission tomography (PET) imaging. TCA-cycle metabolic rate (k(mono)), myocardial efficiency (double product (DP)/k(mono)), and myocardial blood flow (MBF) were determined before and after L-Arg administration. Baseline k(mono) showed a lower value in the M-group than in the C-group (0.051 +/- 0.013 vs 0.070 +/- 0.019 min(-1), P=0.055). On the other hand, baseline DP/k(mono) was significantly greater in the M-group (1.69 +/- 5.9 vs 0.95 +/- 1.2x10(5), P=0.004). After L-Arg administration, 4 patients showed significant elevation of k(mono). No relationship was observed between the distribution of k(mono) elevation and the increase in MBF.
Conclusions: The TCA cycle metabolic rate is markedly suppressed in MELAS patients, indicating a shift in energy production to the anaerobic pathway, leading to a paradoxical increase in myocardial efficiency L-Arg can enhance TCA-cycle metabolism, regardless of its vasodilatation effect, and can be used as a treatment for patients with mitochondrial cardiomyopathy. (Circ J 2010, 74 2702-2711)

• 出版日期2010-12