Glycerol mediated synthesis of 5-substituted 1H-tetrazole under catalyst free conditions

作者：Nandre Kamalakar P; Salunke Jagdish K; Nandre Jitendra P; Patil Vijay S; Borse Amul U; Bhosale Sidhanath V^*

来源：Chinese Chemical Letters, 2012, 23(2): 161-164.

DOI：10.1016/j.cclet.2011.11.019

• 5-Substituted 1H-tetrazole
• [3+2] Cycloaddition
• Nitriles
• Glycerol
• Catalyst free

We have developed simple, cost effective and environmentally benign protocol for the synthesis of 5-substituted 1H-tetrazoles via [2,3] cycloaddition reaction from organic nitriles and sodium azide in glycerol under catalyst free condition. The corresponding 5-substituted 1H-tetrazoles were obtained with good to excellent yields (68-95%).

• 出版日期2012-2