Preparation of Functionalized Organomanganese(II) Reagents by Direct Insertion of Manganese to Aromatic and Benzylic Halides

作者：Peng Zhihua; Knochel Paul^*

来源：Organic Letters, 2011, 13(12): 3198-3201.

DOI：10.1021/ol201109g

Functionalized arylmanganese compounds were prepared using commercial manganese powder in the presence of LiCl and catalytic amounts of both 2.5% InCl3 and 2.5% PbCl2 (THF, 0-50 degrees C). In addition, benzylic manganese reagents are obtained at 25 degrees C in ca. 70-80% yield (in the absence of LiCl) using commercial manganese powder and catalytic amounts of 2.5% InCl3 and 2.5% PbCl2. The resulting organomanganese reagents undergo smooth 1,2-addition, acylation, allylic substitution, Pd-catalyzed cross-coupling, and copper-catalyzed conjugate addition, affording the desired products In good yields.

• 出版日期2011-6-17