A new cytotoxic homoisoflavonoid from Dracaena cambodiana

作者：Liu, Jian; Mei, Wen-Li^*; Wu, Jiao; Zhao, You-Xing; Peng, Ming; Dai, Hao-Fu

来源：Journal of Asian Natural Products Research, 2009, 11(2): 192-195.

DOI：10.1080/10286020802674962

• Dracaena cambodiana
• Agavaceae
• homoisoflavonoid
• cytotoxicity
• cambodianol

A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9g/ml, respectively.

• 出版日期2009
• 单位中国热带农业科学院; 中国科学院昆明植物研究所