Antigiardial activity of glycoproteins and glycopeptides from Ziziphus honey

作者:Mohammed Seif Eldin A; Kabashi Ahmed S; Koko Waleed S; Azim M Kamran*
来源:Natural Product Research, 2015, 29(22): 2100-2102.
DOI:10.1080/14786419.2014.986659

摘要

Natural honey contains an array of glycoproteins, proteoglycans and glycopeptides. Size-exclusion chromatography fractionated Ziziphus honey proteins into five peaks with molecular masses in the range from 10 to >200kDa. The fractionated proteins exhibited in vitro activities against Giardia lamblia with IC50 values 25g/mL. Results indicated that honey proteins were more active as antiprotozoal agents than metronidazole. This study indicated the potential of honey proteins and peptides as novel antigiardial agents.

  • 出版日期2015-11-17