Acquired von Willebrand Disease During CentriMag Support Is Associated with High Prevalence of Bleeding During Support and After Transition to Heart Replacement Therapy

作者：Morrison Kerry A; Jorde Ulrich P; Garan Arthur R; Takayama Hiroo; Naka Yoshifumi; Uriel Nir^*

来源：ASAIO Journal, 2014, 60(2): 241-242.

DOI：10.1097/MAT.0000000000000049

• ventricular assist device
• acquired von Willebrand
• heart replacement therapy
• CentriMag
• bleeding

The Levitronix CentriMag is a magnetically levitated centrifugal-flow pump that can be implanted rapidly in the operating room for both right and left ventricular support. Recently, continuous-flow pumps have been associated with excessive bleeding, which can be at least partially explained by acquired von Willebrand disease (vWD). We investigated whether acquired vWD occurs during CentriMag support and determined the frequency of bleeding complications during device support as well as after transition to long-term support. We found that acquired vWD is common early post CentriMag implantation and is associated with frequent bleeding events and high requirement of blood products.

• 出版日期2014-4